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Antigenic Specificity | Beta-2 Microglobulin (Renal Failure &Tumor Marker) |
Clone | [rB2M/961] |
Host Species | Mouse |
Reactive Species | human and nonhuman primates. |
Isotype | IgG2b, kappa |
Format | unconjugated |
Size | 0.02 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (Without BSA & Azide at 1mg/ml) |
Concentration | n/a |
Applications | Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Recognizes a protein of 12kDa, identified as beta-2 microglobulin. Major histocompatibility complex (MHC) class 1 molecules bind to antigens for presentation on the surface of cells. The proteasome is responsible for producing these antigens from the components of foreign pathogens. MHC class 1 molecules consist of an alphaheavy chain that contains three subdomains (alpha1, alpha2, alpha3) and a non-covalent associating light chain, known as beta-2-Microglobulin. Beta-2-Microglobulin associates with the alpha3 subdomain of the alphaheavy chain and forms an immunoglobulin domain-like structure that mediates proper folding and expression of MHC class 1 molecules. The alpha1 and alpha2 domains of the alphaheavy chain form the peptide antigen-b |
Immunogen | Immunogen: Recombinant Full length human B2M protein Cellular Localization: Cell Surface and Extracellular (Secreted) |
Other Names | [B2M; Beta 2 microglobin; Beta 2 microglobulin; Beta chain of MHC class I molecules; Beta-2-microglobulin form pI 5.3; Hdcma22p] |
Gene, Accession # | [B2M], Gene ID: 567, NCBI: NP_004039.1, UniProt: P61769 |
Catalog # | MBS4380187 |
Price | $190, $340, $340 |
Order / More Info | Beta-2 Microglobulin (Renal Failure &Tumor Marker) Antibody from MYBIOSOURCE INC. |
Product Specific References | Josson, S., et al. 2011. ?2-Microglobulin induces epithelial to mesenchymal transition and confers cancer lethality and bone metastasis in human cancer cells. Cancer Res. 71: 2600-2610. |