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Antigenic Specificity | TNFA |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total TNFA protein. Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.Neville M.J., J. Immunol. 162:4745-4754(1999).Xie T., Genome Res. 13:2621-2636(2003).Kim Y.J., Hum. Mol. Genet. 12:2541-2546(2003). |
Immunogen | Immunogen Type: Peptide Immunogen Description: Synthesized peptide derived from internal of human TNFA. |
Other Names | [Protein name Tumor necrosis factor [Precursor]; TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachectin] |
Gene, Accession # | [TNFA], Gene ID: 7124, NCBI: NP_000585.2, UniProt: P01375 |
Catalog # | MBS9400677 |
Price | $200, $255 |
Order / More Info | TNFA Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |