Edit |   |
---|---|
Antigenic Specificity | IGF1 Receptor (IGF1R) (C-term) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | unconjugated |
Size | 0.08 mL, 0.4 mL |
Concentration | n/a |
Applications | Western Blot (WB), IImmunohistochemistry (IHC) Paraffin |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The IGF1R receptor binds insulin-like growth factor with a high affinity and plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. The protein possess tyrosine kinase activity. |
Immunogen | n/a |
Other Names | [Purified Rabbit (Pab); Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD221; Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain; IGF1R] |
Gene, Accession # | [IGF1R], Gene ID: 3480, NCBI: NP_000866.1, UniProt: P08069 |
Catalog # | MBS9216899 |
Price | $165, $370 |
Order / More Info | IGF1 Receptor (IGF1R) (C-term) Antibody from MYBIOSOURCE INC. |
Product Specific References | Song, R.X., et al., Proc. Natl. Acad. Sci. U.S.A. 101(7):2076-2081 (2004). Zhao, H., et al., Oncogene 23(3):786-794 (2004). Lu, Y., et al., Biochem. Biophys. Res. Commun. 313(3):709-715 (2004). Hakam, A., et al., Dig. Dis. Sci. 48(10):1972-1978 (2003). Li, Y., et al., Arterioscler. Thromb. Vasc. Biol. 23(12):2178-2184 (2003). |