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Antigenic Specificity | MAP4K6 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total MAP4K6 protein. Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1. Isoform 4 can activate the JNK pathway. Involved in the |
Immunogen | Immunogen Type: Peptide Immunogen Description: Synthesized peptide derived from internal of human MAP4K6. |
Other Names | [EC 2.7.11.1; Mitogen-activated protein kinase kinase kinase kinase 6; MAPK/ERK kinase kinase kinase 6; MEK kinase kinase 6; MEKKK 6] |
Gene, Accession # | [MAP4K6], Gene ID: 50488, NCBI: NP_001020108.1, UniProt: Q8N4C8 |
Catalog # | MBS9403918 |
Price | $200, $255 |
Order / More Info | MAP4K6 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |