Estrogen receptor 1, ESR1 / ERalpha Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Estrogen receptor 1, ESR1 / ERalpha |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | immunogen affinity purified |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Estrogen receptor 1 (ESR1, Estrogen receptor alpha, ER-alpha), also known as NR3A1 (nuclear receptor subfamily 3, group A, member 1), is a nuclear receptor that is activated by the sex hormone estrogen. The estrogen receptor (ESR) is a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription.1 Estrogen plays an essential role in the development and maintenance of the skeleton; its effects are mediated via interactions with two estrogen receptor (ER) subtypes, alpha and beta. ER alpha is predominantly expressed in cortical bone, whereas ER beta shows higher levels of expression in cancellous bone.2 And ESR1 amplification in benign and precancerous breast dis |
| Immunogen | Immunogen: A synthetic peptide (conjugated with KLH) corresponding to near C-terminal of human ESR1. |
| Other Names | [Estrogen receptor 1; ESR1 / Eralpha; Estrogen receptor 1; ESR1 / Era], [ESR1; ESR1; ER; ESR; Era; ESRA; ESTRR; NR3A1; ESR; NR3A1; ER] |
| Gene, Accession # | [ESR1 / ER alpha], Gene ID: 2099, NCBI: NP_000116.2, UniProt: P03372 |
| Catalog # | MBS355183 |
| Price | $275 |
| Order / More Info | Estrogen receptor 1, ESR1 / ERalpha Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Dahlman-Wright K, Cavailles V, Fuqua SA, Jordan VC, Katzenellenbogen JA, Korach KS, Maggi A, Muramatsu M, Parker MG, Gustafsson JA (December 2006). International Union of Pharmacology. LXIV. Estrogen receptors. Pharmacol. Rev. 58 (4): 773-81. 2. Bord, S., Horner, A., Beavan, S., Compston, J. Estrogen receptors alpha and beta are differentially expressed in developing human bone. J. Clin. Endocr. Metab. 86: 2309-2314, 2001. 3. Holst, F., Stahl, P. R., Ruiz, C., Hellwinkel, O., Jehan, Z., Wendland, M., Lebeau, A., Terracciano, L., Al-Kuraya, K., Janicke, F., Sauter, G., Simon, R. Estrogen receptor alpha (ESR1) gene amplification is frequent in breast cancer. Nature Genet. 39: 655-660, 2007. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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