Edit |   |
---|---|
Antigenic Specificity | CDKN1A - middle region |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a |
Immunogen | Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CDKN1A |
Other Names | [cyclin-dependent kinase inhibitor 1 isoform 1; Cyclin-dependent kinase inhibitor 1; cyclin-dependent kinase inhibitor 1; cyclin dependent kinase inhibitor 1A; CDK-interacting protein 1; Melanoma differentiation-associated protein 6; MDA-6; p21] |
Gene, Accession # | [CDKN1A], Gene ID: 1026, NCBI: NP_000380.1, UniProt: P38936 |
Catalog # | MBS3223014 |
Price | $335 |
Order / More Info | CDKN1A - middle region Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |