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Antigenic Specificity | DNJC2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.03 mL, 0.1 mL, 0.2 mL |
Concentration | 1 mg/ml |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of DNJC2 protein. Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at Lys-119 (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilita |
Immunogen | Immunogen: Synthesized peptide derived from part region of human DNJC2 protein |
Other Names | [Rabbit DNJC2; DnaJ homolog subfamily C member 2; M-phase phosphoprotein 11; Zuotin-related factor 1] |
Gene, Accession # | [DNJC2], Gene ID: 27000, NCBI: Q99543.4, UniProt: Q99543 |
Catalog # | MBS9708982 |
Price | $130, $220, $325 |
Order / More Info | DNJC2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |