DTNBP1 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | DTNBP1 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL, 0.2 mL |
| Concentration | 1mg/ml |
| Applications | Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: DTNBP1 antibody detects endogenous levels of total DTNBP1. Description: Dysbindin, or dystrobrevin-binding protein 1, is a coiled-coil-containing protein expressed in muscle and brain that was identified as a binding partner of dystrobrevin (1). Dysbindin upregulates expression of the pre-synaptic proteins SNAP25 and synapsin I, thereby increasing glutamate release and promoting neuronal viability through Akt signaling. In particular, Akt phosphorylation is suppressed with downregulation of dysbindin and increased with upregulation of dysbindin (2). A nonsense mutation of dysbindin causes Hermansky-Pudlak disease, an autosomal recessive disorder characterized by lysosomal storage defects and prolonged bleeding. (2). Genetic var |
| Immunogen | Immunogen: A synthesized peptide derived from human DTNBP1 Subcellular Location: Cytoplasm. Cytoplasmic Vesicle Membrane. Cytoplasmic Vesicle > Secretory Vesicle > Synaptic Vesicle Membrane. Endosome Membrane. Melanosome Membrane. Nucleus. Cell Junction > Synapse > Postsynaptic Cell Membrane > Postsynaptic Density. Endoplasmic Reticulum. Detected in neuron cell bodies, axons and dendrites. Detected at synapses, at post-synaptic density, at pre-synaptic vesicle membranes and microtubules. Detecte |
| Other Names | [DTBP1_HUMAN; DTNBP1; Dysbindin; Dysbindin-1; Dystrobrevin binding protein 1; Dystrobrevin-binding protein 1; Hermansky Pudlak syndrome 7 protein; Hermansky-Pudlak syndrome 7 protein; HPS7; HPS7 protein] |
| Gene, Accession # | [DTNBP1], Gene ID: 84062, NCBI: NP_001258596.1, UniProt: Q96EV8 |
| Catalog # | MBS9607173 |
| Price | $240, $280 |
| Order / More Info | DTNBP1 Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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