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Antigenic Specificity | VCL |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.06 mL, 0.12 mL, 0.2 mL |
Concentration | 1mg/mL |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Vinculin is a cytoskeletal protein that plays an important role in the regulation of focal adhesions and embryonic development (1-4). Three structural vinculin domains include an amino-terminal head, a short, flexible proline-rich region and a carboxy-terminal tail (1). In the inactive state, the head and tail domains of vinculin interact to form a closed confirmation. The open and active form of vinculin translocates to focal adhesions where it is thought to be involved in anchoring F-actin to the membrane and regulation of cell migration (2). Phospholipid binding to the tail domain and subsequent phosphorylation of vinculin at Ser1033 and Ser1045 by PKC-alpha and Tyr100 and Tyr1065 by Src kinases weakens the head-tail interaction (5, 6). |
Immunogen | Immunogen: Recombinant protein of human VCL Observed Molecular Weight: 124kDa |
Other Names | [MV; MVCL; CMD1W; CMH15] |
Gene, Accession # | [VCL], Gene ID: 7414, NCBI: NP_003364.1 |
Catalog # | MBS2520362 |
Price | $150, $225, $360 |
Order / More Info | VCL Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |