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Antigenic Specificity | MALT1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.06 mL, 0.12 mL, 0.2 mL |
Concentration | 1mg/mL |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Mucosa-associated lymphoid tissue translocation gene 1 (MALT1) is a paracaspase that is a critical mediator of T-cell receptor activation of NF-kappaB and may contribute to the progression of MALT lymphomas (1-4). It contains two immunoglobulin-like domains, an amino-terminal death domain and a carboxy-terminal caspase-like domain. Association of MALT1 with Bcl-10 and CARD11/Carma1 leads to activation of IKK and subsequent stimulation of NF-kappaB, resulting in increased proliferation and inhibition of apoptosis (5, 6). A common translocation in MALT B-cell non-Hodgkin lymphomas t(11; 18)(q21; q21) results in the fusion of the amino terminus of API2 (c-IAP2), a member of the inhibitor of apoptosis protein family, to the carboxy terminus of |
Immunogen | Immunogen: Recombinant protein of human MALT1 Observed Molecular Weight: 92kDa |
Other Names | [DKFZp434L132; MLT; MLT1] |
Gene, Accession # | [MALT1], Gene ID: 10892, NCBI: NP_776216.1 |
Catalog # | MBS2528997 |
Price | $150, $225, $360 |
Order / More Info | MALT1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |