Interleukin 6, IL-6 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Interleukin 6, IL-6 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | mouse |
| Isotype | n/a |
| Format | immunogen affinity purified |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | Western Blot (WB), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | IL-6 is an immunoregulatory cytokine that activates a cell surface signaling assembly composed of IL6, IL6RA, and the shared signaling receptor gp130. [1] It belongs to the IL-6 superfamily. And It is secreted by T cells and macrophages to stimulate immune response. IL-6 is one of the most important mediators of fever and of the acute phase response. It is capable of crossing the blood brain barrier[2] and initiating synthesis of PGE2 in the hypothalamus, thereby changing the body's temperature setpoint. It also plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation.[3] |
| Immunogen | Immunogen: A synthetic peptide (conjugated to KLH) corresponding to the region of mouse IL-6. |
| Other Names | [Interleukin 6; IL-6], [IL6; IL6; IL-6] |
| Gene, Accession # | [IL-6], Gene ID: 399500, NCBI: NP_999564.1, UniProt: P26893 |
| Catalog # | MBS355074 |
| Price | $275 |
| Order / More Info | Interleukin 6, IL-6 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Boulanger, M. J., Chow, D., Brevnova, E. E., Garcia, K. C. Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex. Science 300: 2101-2104, 2003. 2. Banks WA, Kastin AJ, Gutierrez EG (September 1994). Penetration of interleukin-6 across the murine blood-brain barrier. Neurosci. Lett. 179 (1-2): 53-6. 3. Hirano, T., Yasukawa, K., Harada, H., Taga, T., Watanabe, Y., Matsuda, T., Kashiwamura, S., Nakajima, K., Koyama, K., Iwamatsu, A., Tsunasawa, S., Sakiyama, F., Matsui, H., Takahara, Y., Taniguchi, T., Kishimoto, T. Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature 324: 73-76, 1986. |
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