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Antigenic Specificity | HIRA (N-term), 32-61 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human (predicted reactivity: mouse) |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 0.5 |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This HIRA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 32-61 amino acids from the N-terminal region of human HIRA. This gene encodes a histone chaperone that preferentiallyplaces the variant histone H3.3 in nucleosomes. Orthologs of thisgene in yeast, flies, and plants are necessary for the formation oftranscriptionally silent heterochomatin. This gene plays animportant role in the formation of the senescence-associatedheterochromatin foci. These foci likely mediate the irreversiblecell cycle changes that occur in senescent cells. It is consideredthe primary candidate gene in some haploinsufficiency syndromessuch as DiGeorge syndrome, and insufficient production |
Immunogen | n/a |
Other Names | [Protein HIRA; TUP1-like enhancer of split protein 1; HIRA; DGCR1; HIR; TUPLE1] |
Gene, Accession # | [HIRA], Gene ID: 7290, NCBI: NP_003316.3, UniProt: P54198 |
Catalog # | MBS9211903 |
Price | $165, $370 |
Order / More Info | HIRA (N-term), 32-61 Antibody from MYBIOSOURCE INC. |
Product Specific References | Bailey, S.D., et al. Diabetes Care (2010) In press : Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009) Banumathy, G., et al. Mol. Cell. Biol. 29(3):758-770(2009) Ramelli, G.P., et al. Dev Med Child Neurol 50(12):953-955(2008) Zhang, R., et al. Mol. Cell. Biol. 27(6):2343-2358(2007) |