Edit |   |
---|---|
Antigenic Specificity | PAK4 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat, hamster |
Isotype | n/a |
Format | affinity purified |
Size | 0.03 mg, 0.1 mg |
Concentration | 0.5 mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Background: The PAK (p21-activated kinase) family of serine/threonine kinases plays an important role in multiple cellular processes, including cytoskeletal reorganization, MAPK signaling, apoptotic signaling, etc. Several mechanisms that induce PAK activation have been reported. Binding of Rac/cdc42 to the CRIB (or PBD) domain at the N-terminal region of PAK causes autophosphorylation and conformational change of PAK. More recently identified members PAK4, PAK5 and PAK6 have lower sequence similarity with PAK1-3 in the regulatory N-terminal region. It has been demonstrated that phosphorylation of serine 474 of PAK4 may play a pivotal role in the activity and function of PAK4 kinase |
Immunogen | Immunogen: Synthetic peptide corresponding to the N-terminus of human Pak4 |
Other Names | n/a |
Gene, Accession # | [PAK4], NCBI: BAF84528 |
Catalog # | MBS841190 |
Price | $150, $290 |
Order / More Info | PAK4 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |