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Antigenic Specificity | eIF4E |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.05 mL, 0.1 mL, 0.2 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP), Flow Cytometry (FC/FACS) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Rabbit polyclonal to Human eIF4E. Eukaryotic initiation factor 4E (eIF4E) binds to the mRNA cap structure to mediate the initiation of translation (1,2). eIF4E interacts with eIF4G, a scaffold protein that promotes assembly of eIF4E and eIF4A into the eIF4F complex (2). eIF4B is thought to assist the eIF4F complex in translation initiation. Upon activation by mitogenic and/or stress stimuli mediated by Erk and p38 MAPK, Mnk1 phosphorylates eIF4E at Ser209 in vivo (3,4). Two Erk and p38 MAPK phosphorylation sites in mouse Mnk1 (Thr197 and Thr202) are essential for Mnk1 kinase activity (3). The carboxy-terminal region of eIF4G also contains serum-stimulated phosphorylation sites, including Ser1108, Ser1148, and Ser1192 (5). Phosphorylation at |
Immunogen | Immunogen: A synthetic -peptide of human eIF4E |
Other Names | [EIF4E; eIF4E; eIF4E; EIF4E; CBP; EIF4E1; EIF4EL1; EIF4F; MGC111573; Eukaryotic translation initiation factor 4E; eIF-4F 25 kDa subunit; mRNA cap-binding protein;], [EIF4E; EIF4E; CBP; EIF4F; AUTS19; EIF4E1; EIF4EL1; EIF4EL1; EIF4F; eIF-4E; eIF4E] |
Gene, Accession # | Gene ID: 1977, NCBI: NP_001124150.1, UniProt: P06730 |
Catalog # | MBS125877 |
Price | $200, $275, $430 |
Order / More Info | eIF4E Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Sonenberg, N. et al. (1978) Proc. Natl. Acad. Sci. USA 75, 4843-4847. 2. Gingras, A.C. et al. (1999) Annu. Rev. Biochem. 68, 913-963. 3. Waskiewicz, A. et al. (1999) Mol. Cell. Biol. 19, 1871-1880. 4. Pyronnet, S. et al. (1999) EMBO J. 18, 270-279. 5. Raught, B. et al. (2000) EMBO J. 19, 434-444. |