MAP3K8 (Phospho-Ser400) Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityMAP3K8 (Phospho-Ser400)
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman
Isotypen/a
Formatepitope affinity purified
Size0.05 mL, 0.1 mL
Concentration1.0 mg/ml
ApplicationsImmunohistochemistry (IHC)
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DescriptionThe antibody detects endogenous levels of MAP3K8 only when phosphorylated at serine 400. This gene was identified by its oncogenic transforming activity in cells. The encoded protein is a member of the serine/threonine protein kinase family. This kinase can activate both the MAP kinase and JNK kinase pathways. This kinase was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This kinase was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. Studies of a similar gene in rat suggested the direct involvement of this kinase in the proteolysis of NF-kappaB1,p105 (NFKB1). Miyoshi J., Mol. Cell. Biol. 11:4088-4096(1991).Aoki M., J. Biol. Chem. 268:22723-22732(1993).Chan
ImmunogenImmunogen Type: Peptide-KLH Immunogen Description: Peptide sequence around phosphorylation site of Serine 400(C-Q-S(p)-L-D) derived from HumanMAP3K8.
Other Names[C-COT;; M3K8; MAP3K8; TPL2]
Gene, Accession #[MAP3K8], Gene ID: 1326, NCBI: NP_001231063.1, UniProt: P41279
Catalog #MBS9401112
Price$200, $255
Order / More InfoMAP3K8 (Phospho-Ser400) Antibody from MYBIOSOURCE INC.
Product Specific Referencesn/a
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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