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Antigenic Specificity | MAP3K8 (Phospho-Ser400) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | epitope affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of MAP3K8 only when phosphorylated at serine 400. This gene was identified by its oncogenic transforming activity in cells. The encoded protein is a member of the serine/threonine protein kinase family. This kinase can activate both the MAP kinase and JNK kinase pathways. This kinase was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This kinase was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. Studies of a similar gene in rat suggested the direct involvement of this kinase in the proteolysis of NF-kappaB1,p105 (NFKB1). Miyoshi J., Mol. Cell. Biol. 11:4088-4096(1991).Aoki M., J. Biol. Chem. 268:22723-22732(1993).Chan |
Immunogen | Immunogen Type: Peptide-KLH Immunogen Description: Peptide sequence around phosphorylation site of Serine 400(C-Q-S(p)-L-D) derived from HumanMAP3K8. |
Other Names | [C-COT;; M3K8; MAP3K8; TPL2] |
Gene, Accession # | [MAP3K8], Gene ID: 1326, NCBI: NP_001231063.1, UniProt: P41279 |
Catalog # | MBS9401112 |
Price | $200, $255 |
Order / More Info | MAP3K8 (Phospho-Ser400) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |