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Antigenic Specificity | Human-PIK3R2(Y464) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | unconjugated |
Size | 0.05 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 430-470 amino acids from human. Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5- trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regula |
Immunogen | n/a |
Other Names | [Purified Rabbit (Pab); Phosphatidylinositol 3-kinase regulatory subunit beta; PI3-kinase regulatory subunit beta; PI3K regulatory subunit beta; PtdIns-3-kinase regulatory subunit beta; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta; PI3-kinase subunit p85-beta; PtdIns-3-kinase regulatory subunit p85-beta; PIK3R2] |
Gene, Accession # | [PIK3R2], Gene ID: 5296, NCBI: NP_005018.1, UniProt: O00459 |
Catalog # | MBS9215922 |
Price | $150 |
Order / More Info | Human-PIK3R2(Y464) Antibody from MYBIOSOURCE INC. |
Product Specific References | Volinia S.,et al.Oncogene 7:789-793(1992).Janssen J.W.G.,et al.Oncogene 16:1767-1772(1998).Grimwood J.,et al.Nature 428:529-535(2004).Braunger J.,et al.Oncogene 14:2619-2631(1997).Igarashi K.,et al.Biochem. Biophys. Res. Commun. 246:95-99(1998). |