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Antigenic Specificity | IL10 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | rat, mouse |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.02 mL, 0.06 mL, 0.12 mL |
Concentration | 3mg/ml |
Applications | Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Interleukin (IL)-10 is an anti-inflammatory cytokine, produced by T helper (Th) cells, macrophages, monocytes, and B cells, that plays a crucial role in preventing inflammatory and autoimmune pathologies. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-kappaB activity, and is involved in the regulation of the JAK-STAT signaling pathway. IL-10, along with its receptors, describes an important role in pathogenesis of various diseases, including infectious, inflammatory, autoimmune diseases. IL-10 mutations are associated with an increased susceptibility to HIV-1 infection and rheuma |
Immunogen | Immunogen: Recombinant Mouse Interleukin-10 protein Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Other Names | [CSIF; IL10; IL-10; IL10A; interleukin 10; TGIF] |
Gene, Accession # | [IL10], Gene ID: 3586, UniProt: Q6FGS9 |
Catalog # | MBS2541767 |
Price | $110, $150, $225 |
Order / More Info | IL10 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |