hChk1-S280 Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | hChk1-S280 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | Protein A purified |
| Size | 0.05 mL, 0.2 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between amino acids from human. Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome. Recognizes the substrate consensus sequence [R-X-X-S/T]. Binds to and phosphorylates CDC25A, CDC25B and CDC25C. Phosphorylation of CDC25A at 'Ser-178' and 'Thr-507' and phosphorylation of CDC25C at 'Ser-216' creates binding sites for 14-3-3 prot |
| Immunogen | n/a |
| Other Names | [Serine/threonine-protein kinase Chk1; 2.7.11.1; CHK1 checkpoint homolog; Cell cycle checkpoint kinase; Checkpoint kinase-1; CHEK1; CHK1] |
| Gene, Accession # | [hChk1-S280], Gene ID: 1111, NCBI: NP_001107593.1, UniProt: O14757 |
| Catalog # | MBS9231347 |
| Price | $165, $370 |
| Order / More Info | hChk1-S280 Antibody from MYBIOSOURCE INC. |
| Product Specific References | Sanchez Y.,et al.Science 277:1497-1501(1997). Flaggs G.,et al.Curr. Biol. 7:977-986(1997). Semba S.,et al.Int. J. Oncol. 16:731-737(2000). Pabla N.,et al.Proc. Natl. Acad. Sci. U.S.A. 109:197-202(2012). Ota T.,et al.Nat. Genet. 36:40-45(2004). |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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