Edit |   |
Antigenic Specificity | Human DRP1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Dynamin-related protein 1 (DRP1) is a member of the dynamin superfamily of GTPases. Members of this family have diverse cellular functions including vesicle scission, organelle fission, viral resistance, and intracellular trafficking (reviewed in 1). DRP1 affects mitochondrial morphology and is important in mitochondrial and peroxisomal fission in mammalian cells (2-5). The yeast ortholog of DRP1 clusters into a spiral-shaped structure on the mitochondrial membrane at the site of fission (reviewed in 6), and this structure is likely conserved in mammalian cells (3). The division of the mitochondria, which is required for apoptosis as well as normal cell growth and development, is controlled, in part, by the phosphorylation of DRP1 at Ser616 |
Immunogen | Immunogen: A fusion protein of human DRP1 |
Other Names | [DRP1 Rabbit pab], [DNM1L; DLP1; DRP1; DVLP; DYMPLE; DYNIV-11; FLJ41912; HDYNIV; VPS1] |
Gene, Accession # | [DRP1], Gene ID: 10059, NCBI: NP_005681.2, UniProt: O00429 |
Catalog # | MBS125938 |
Price | $275, $430 |
Order / More Info | Human DRP1 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Praefcke, G.J. and McMahon, H.T. (2004) Nat Rev Mol Cell Biol 5, 133-47.2. Taguchi, N. et al. (2007) J Biol Chem 282, 11521-9.3. Smirnova, E. et al. (2001) Mol Biol Cell 12, 2245-56.4. Smirnova, E. et al. (1998) J Cell Biol 143, 351-8.5. Koch, A. et al. (2003) J Biol Chem 278, 8597-605. |