Edit |   |
---|---|
Antigenic Specificity | IL-33 (Interleukin-33, IL-1F11, NF-HEV) |
Clone | [Bondy-1-1] |
Host Species | Mouse |
Reactive Species | mouse |
Isotype | IgG2b |
Format | Protein A purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Recognizes mouse IL-33. Interleukin-33 (IL-33; HF-NEV; IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released upon cell lysis. IL-33 binds to and signals through ST2 (IL-1R1) and its stimulation recruits MYD88, IRAK, IRAK4 and TRAF6, followed by phosphorylation of ERK1 (MAPK3)/ERK2 (MAPK1), p38 (MAPK14) and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous |
Immunogen | Immunogen: Recombinant protein corresponding to mouse IL-33 expressed in HEK 293 cell culture supernatant. |
Other Names | n/a |
Gene, Accession # | [IL-33] |
Catalog # | MBS6120617 |
Price | $610 |
Order / More Info | IL-33 (Interleukin-33, IL-1F11, NF-HEV) Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Regulation of de novo adipocyte differentiation through crosstalk between adipocytes and pre-adipocytes: T.D. Challa, et al.; Diabetes 64, 4075 (2015). |