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Antigenic Specificity | CASP7 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of total CASP7 protein. Caspase-7 (CMH-1, Mch3, ICE-LAP3) has been identified as a major contributor to the execution of apoptosis (1-4). Caspase-7, like caspase-3, is an effector caspase that is responsible for cleaving downstream substrates such as (ADP-ribose) polymerase and PARP (1,3). During apoptosis, caspase-7 is activated through proteolytic processsing by upstream caspases at Asp23, Asp198, and Asp206 to produce the mature subunits (1,3). Similar to caspases-2 and -3, caspase-7 preferentially cleaves substrates following the recognition sequence DEVD (5). |
Immunogen | Immunogen Type: Recombinant Protein Immunogen Description: Recombinant protein of human CASP7. |
Other Names | [CMH-1; ICE-LAP3; MCH3; CASP7; Caspase-7] |
Gene, Accession # | [CASP7], Gene ID: 840, NCBI: NP_001218.1, UniProt: P55210 |
Catalog # | MBS9414269 |
Price | $255 |
Order / More Info | CASP7 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |