ALK (Anaplastic Lymphoma Kinase)/CD246 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | ALK (Anaplastic Lymphoma Kinase)/CD246 |
| Clone | [ALK/1031] |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2b, kappa |
| Format | purified |
| Size | 0.02 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (Without BSA & Azide at 1mg/ml) |
| Concentration | n/a |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The wild-type anaplastic lymphoma kinase (ALK) protein is a 200kDa transmembrane receptor tyrosine kinase. Its expression is restricted to a few scattered cells in the nervous system (some glial cells and neurons, and a few endothelial cells and pericytes. The hybrid gene,NPM-ALK, created by the t(2;5)(p23;q35) chromosomal translocation encodes part of the nucleolar phosphoprotein, nucleophosmin (NPM), joined to the entire cytoplasmic portion of the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase. As a consequence, the ALK gene comes under the control of the NPM promoter, which induces a permanent and ubiquitous transcription of the NPM-ALK hybrid gene, resulting in the production of a 80kDa NPM-ALK chimeric protein. This transloc |
| Immunogen | Immunogen: Recombinant human ALK protein fragment covering ~aa400-500. |
| Other Names | [ALK Tyrosine Kinase Receptor; ALK/NPM1 fusion gene; Anaplastic lymphoma kinase Ki1; Anaplastic Lymphoma Kinase p80; anaplastic lymphoma receptor tyrosine kinase; CD246; mutant anaplastic lymphoma kinase; NBLST3; Tcrz; TFG/ALK] |
| Gene, Accession # | [ALK], Gene ID: 238, NCBI: NP_004295.2, UniProt: Q9UM73 |
| Catalog # | MBS4380914 |
| Price | $190, $340, $340 |
| Order / More Info | ALK (Anaplastic Lymphoma Kinase)/CD246 Antibody from MYBIOSOURCE INC. |
| Product Specific References | Pulford K, Lamant L, Morris SW, Butler LH, Wood KM, Stroud D, et al. Detection of anaplastic lymphoma kinase (ALK) and nucleolar protein nucleophosmin (NPM)-ALK proteins in normal and neoplastic cells with the monoclonal antibody ALK1. Blood 1997;89:1394-404. |
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