Akt (N-terminal Region) Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | Akt (N-terminal Region) |
| Clone | monoclonal |
| Host Species | Mouse |
| Reactive Species | human, rat, mouse |
| Isotype | IgG1 |
| Format | Protein A purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | ELISA, Western Blot, Immunocytochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This antibody detects a 60 kDa* protein corresponding to the apparent molecular mass of Akt on SDS-PAGE immunoblots of A431 cell lysate. Similar results were seen in various other human, rat, and mouse lysates. Akt (PKB, Rac kinase) is a 60kDa ser/thr kinase critical for controlling diverse cellular functions, including glucose metabolism, gene transcription, cell proliferation, and apoptosis. Akt phosphorylates a number of substrates including MBP, glycogen synthetase, PKA RII subunit, and histone H1. Akt is activated in response to insulin and growth factors in a PI3-kinase dependent manner. Activation of PI3-Kinase generates phosphatidylinositol 3,4-bisphosphate, which induces membrane translocation of Akt coincident with its phosphoryla |
| Immunogen | Immunogen: Clone M101 was generated from a recombinant protein containing amino acid residues in the N-terminal region of human Akt1. This sequence ishighly conserved in human and mouse Akt, and may recognize Akt2 and Akt3. |
| Other Names | n/a |
| Gene, Accession # | n/a |
| Catalog # | MBS470001 |
| Price | $325 |
| Order / More Info | Akt (N-terminal Region) Antibody from MYBIOSOURCE INC. |
| Product Specific References | • Jones, P.F. et al. (1991) Proc. Natl. Acad. Sci. USA 88:4171-4175.• Marte, B. & Downward. J. (1997) TIBS. 22:355-358.• Powell, D.J. et al. (2003) Mol. Cell Biol. 23:7794-7808.• Smith, M.A. et al. (2007) Am. J. Phys. Cell. Phys. 293:1947. (WB: mouse C2C12)• Moylan, J.S. et al. (2008) Am. J. Phys. Cell. Phys. 295:986. (WB: mouse C2C12) |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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