CDK5R1 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | CDK5R1 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunofluorescence (IF) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated prote |
| Immunogen | Immunogen: Recombinant protein of human CDK5R1 (NP 003876.1). |
| Other Names | [cyclin-dependent kinase 5 activator 1; Cyclin-dependent kinase 5 activator 1; cyclin-dependent kinase 5 activator 1; cyclin dependent kinase 5 regulatory subunit 1; Cyclin-dependent kinase 5 regulatory subunit 1; TPKII regulatory subunitCleaved into the following 2 chains:Cyclin-dependent kinase 5 activator 1, p35; p35Cyclin-dependent kinase 5 activator 1, p25; p25; Alternative name(s):; Tau protein kinase II 23 kDa subunit] |
| Gene, Accession # | [CDK5R1], Gene ID: 8851, NCBI: NP_003876.1, UniProt: Q15078 |
| Catalog # | MBS8569190 |
| Price | $280 |
| Order / More Info | CDK5R1 Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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