Alpha-Actin, sarcomeric Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Alpha-Actin, sarcomeric |
| Clone | polyclonal |
| Host Species | Mouse |
| Reactive Species | human, amphibia, Bony fish, Cattle, guinea pig, reptiles, rabbit, rat, sheep |
| Isotype | n/a |
| Format | unconjugated |
| Size | 1 mL |
| Concentration | n/a |
| Applications | Immunohistochemistry (IHC) Formalin/Paraffin |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The antibody 5C5 which is directed against sarcomeric alpha-actin labels skeletal and heart muscle cells but not smooth muscle cells. In neoplasms it may be used as a marker of rhabdomyosarcoma. Movement of cell organelles, cells, and organisms depends on the interaction of the cytoskeletal proteins actin and myosin. In birds and mammals up to now six different isoforms of actin have been identified using amino acid sequence analysis and electrophoresis. They are more or less specific for different organs resp. cell types. Four isoforms are known to occur in muscle cells, while two other forms are found in most other cell types. Alpha-Actin sarcomeric (a-sr-1) specific for skeletal- and heart-muscle. |
| Immunogen | Immunogen: Purified rabbit skeletal muscle actin |
| Other Names | [actin, alpha skeletal muscle; Actin, alpha skeletal muscle; actin, alpha skeletal muscle; actin, alpha 1, skeletal muscle; Alpha-actin-1], [ACTA1; ACTA1; ACTA; ASMA; CFTD; MPFD; NEM1; NEM2; NEM3; SHPM; CFTD1; CFTDM; ACTA] |
| Gene, Accession # | Gene ID: 58, NCBI: NP_001091.1, UniProt: P68133 |
| Catalog # | MBS396747 |
| Price | $485 |
| Order / More Info | Alpha-Actin, sarcomeric Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Skalli O, Gabbiani G, Babai F, Seemayer TA, Pizzolato G, Schurch W. Intermediate filament proteins and actin isoforms as markers for soft tissue tumor differentiation and origin. II. Rhabdomyosarcomas. Am. J. Pathol., 130; 515ff (1988) 2. Babai F, Skalli O, Schurch W, Seemayer TA, Gabbiani G. Chemically induced rhabdomyosarcomas in rats. Ultrastructural, immunohistochemical, biochemical features and expression of alpha-actin isoforms. Virchows Arch B Cell Pathol Incl Mol Pathol. 1988;55(5):263-77. 3. Hasegawa T, Matsuno Y, Niki T, Hirohashi S, Shimoda T, Takayama J, Watanabe C, Kaneko A, Sano T, Sato M, Suzuki J. Second primary rhabdomyosarcomas in patients with bilateral retinoblastoma: a clinicopathologic and immunohistochemical study. Am J Surg Pathol. 1998 Nov;22(11):1351-60. 4. Eusebi V, Damiani S, Pasquinelli G, Lorenzini P, Reuter VE, Rosai J. Small cell neuroendocrine carcinoma with skeletal muscle differentiation: report of three cases. Am J Surg Pathol. 2000 Feb;24(2):223-30. Review. 5. Tornoczky T, Kalman E, Sapi Z, Orosz Z, Pajor L. Cytogenetic abnormalities of alveolar soft-part sarcomas using interphase fluorescent in situ hybridization: trisomy for chromosome 7 and monosomy for chromosomes 8 and 18 seem to be characteristic of the tumor. Virchows Arch. 2001 Feb;438(2):173-80. |
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MYBIOSOURCE INC.
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