Edit |   |
Antigenic Specificity | Mouse CD40 |
Clone | [FGK4.5/FGK45] |
Host Species | Rat |
Reactive Species | mouse |
Isotype | IgG2a |
Format | unconjugated |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | Flow Cytometry (FC/FACS) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD40 is a 48 kD type I transmembrane glycoprotein also known as Bp50. It is a member of the tumor necrosis factor receptor (TNFR) superfamily and is expressed on B cells, basal epithelial cells, macrophages, follicular dendritic cells, endothelial cells, and a subset of CD34+ hematopoietic progenitors. CD40 regulates B cell development/maturation, Ig isotype switching and, in combination with other signals such as IL-4, protects B cells from surface Ig-induced apoptosis and promotes proliferation. Interaction of CD40 with its ligand CD154 (gp39), which is expressed on activated T cells, is important in costimulation and immune regulation. |
Immunogen | n/a |
Other Names | [Mouse CD40; Tumor necrosis factor receptor superfamily member 5; Cd40; B-cell surface antigen CD40; Bp50; CD40L receptor; CD40; Tnfrsf5] |
Gene, Accession # | [CD40], Gene ID: 21939, NCBI: NP_035741.2, UniProt: P27512 |
Catalog # | MBS2553793 |
Price | $90, $110 |
Order / More Info | Mouse CD40 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Hasbold J, Johnson-Leger C, Atkins CJ, Clark EA, Klaus GG. Eur J Immunol. 1994; 24(8):1835-1842. 2. Hasbold J, Klaus GG. Eur J Immunol. 1994; 24(1):152-157. 3. Klaus GG, Holman M, Hasbold J. Eur J Immunol. 1994; 24(11):2714-2719. 4. Noelle RJ, Ledbetter JA, Aruffo A. Immunol Today. 1992; 13(11):431-433. 5. Parry SL, Hasbold J, Holman M, Klaus GG. J Immunol. 1994; 152(6):2821-2829. |