Girdin (Ser-1674), Phospho-Specific Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Girdin (Ser-1674), Phospho-Specific |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, rat, mouse |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The antibody was cross-adsorbed to unphosphorylated Girdin (Ser-1674) peptide before affinity purification using phospho-Girdin (Ser-1674) peptide. This antibody detects a 250 kDa* protein on SDS-PAGE immunoblots of human A431 cells stimulated with Calyculin A. This reactivity is not observed after lambda phosphatase treatment to dephosphorylate Girdin. Girdin, a member of the CCDC88 (Hook related protein) family, is an actin binding protein involved with cell migration and maintaining cytoskeletal organization. Girdin has conserved domains at the N- and C-terminus that bind microtubules and actin, respectively. It enhances PI3-kinase dependent phosphorylation of proteins, most notably Akt. This same activity can contribute to tumor prolife |
| Immunogen | Immunogen: Phospho-Girdin (Ser-1674) synthetic peptide (coupled to carrier) corresponding to amino acid residues around serine 1674 in human Girdin. This sequence has high homology to rat and mouse Girdin, and has low homology to similar regions in other Girdin family members. |
| Other Names | [APE; Galpha; vesicle; GIV; Girders actin filament; HkRP1; GRDN; CCDC88A], [CCDC88A; CCDC88A; APE; GIV; GRDN; PEHO; HkRP1; PEHOL; GIRDIN; KIAA1212; APE; GRDN; KIAA1212; APE; GIV; HkRP1] |
| Gene, Accession # | Gene ID: 55704, NCBI: NP_001129069.1, UniProt: Q3V6T2 |
| Catalog # | MBS474104 |
| Price | $385 |
| Order / More Info | Girdin (Ser-1674), Phospho-Specific Antibody from MYBIOSOURCE INC. |
| Product Specific References | Simpson, F. (2005) Traffic. 6(6):442Jiang, P. (2008) Cancer Res. 1;68(5):1310Bhandari, D. et al. (2009) Mol Biol Cell. 20:1324.Lin, C. (2011) Sci Signal. 4(192): ra64Lin, C. et al. (2014) Mol Biol Cell. 25(22):3654Hayano S. et al, (2015) J Mol Cell Cardiol. 88:55. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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