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Antigenic Specificity | Lamin A/C |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | n/a |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunocytochemistry (ICC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Lamins are structural protein components of the nuclear lamina, a protein network underlying the inner nuclear membrane that determines nuclear shape and size. There are three types of lamins, A, B and C. The lamin A/C (LMNA) gene contains 12 exons. Alternative splicing within exon 10 gives rise to two different mRNAs that code for pre-lamin A and lamin C. Lamin A/C mapped to 1q21.2-q21.3 and mutations in this gene cause a variety of human diseases including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy and Hutchinson-Gilford progeria syndrome. Lamin A/C deficiency is thus associated with both defective nuclear mechanics and impaired mechanically activated gene transcription. |
Immunogen | Immunogen: Lamin A/C antibody was raised in Rabbit using a synthetic peptide corresponding to a sequence at the C-terminal of human Lamin A/C, identical to the related rat and Rabbit sequences, as the immunogen |
Other Names | [Affinity Purified Rabbit Lamin A/C; Lamin A/C; Lamin A/C; Lamin C; Lamin A] |
Gene, Accession # | [LMN1] |
Catalog # | MBS5312587 |
Price | $345 |
Order / More Info | Lamin A/C Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |