Human CD262 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Human CD262 |
| Clone | polyclonal |
| Host Species | Goat |
| Reactive Species | mouse |
| Isotype | n/a |
| Format | unconjugated |
| Size | 0.1 mg |
| Concentration | IgG concentration 1.0 mg/ml |
| Applications | ELISA (EIA), Flow cytometry (FC/FACS), Immunohistology Paraffin |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This item recognises CD262, otherwise known as DR5/TRAIL-R2, a broadly expressed death domain containing receptor and member of the TNF-receptor superfamily, which acts as a mediator for CD253/TRAIL induced apoptosis in a variety of tumor and transformed cells, but not in normal cells. Expression of CD262 is regulated by tumor suppressor p53, and CD262 is highly expressed by tumour cell lines. Studies suggest that the death domain containing adaptor protein FADD, is required for CD262-mediated apoptosis, and that FADD recruits caspase-8 to the activated receptor. This item is reported as suitable for use in immunocytochemistry. MBS224046 recognises CD262, otherwise known as DR5/TRAIL-R2, a broadly expressed death domain containing receptor |
| Immunogen | Immunogen: Synthetic peptide APQQKRSSPSEGLCPPGHHISEDGRDC corresponding to amino acids 68-94 of the extracellular domain of human CD262. Histology Positive Control Tissue: Spleen Buffer Solution: Phosphate buffered saline Antiserum Preparation: Antiserum to human CD262 was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography. Target Species: Human |
| Other Names | [tumor necrosis factor receptor superfamily member 10B isoform 1; Tumor necrosis factor receptor superfamily member 10B; tumor necrosis factor receptor superfamily member 10B; Fas-like protein; TNF receptor superfamily member 10b; TNF-related apoptosis-inducing ligand receptor 2; apoptosis inducing protein TRICK2A/2B; apoptosis inducing receptor TRAIL-R2; cytotoxic TRAIL receptor-2; death domain containing receptor for TRAIL/Apo-2L; death receptor 5; p53-regulated DNA damage-inducible cell death receptor(killer); tumor necrosis factor receptor-like protein ZTNFR9; tumor necrosis factor receptor superfamily, member 10b; Death receptor 5; TNF-related apoptosis-inducing ligand receptor 2; TRAIL receptor 2; TRAIL-R2; CD_antigen: CD262], [TNFRSF10B; TNFRSF10B; DR5; CD262; KILLER; TRICK2; TRICKB; ZTNFR9; TRAILR2; TRICK2A; TRICK2B; TRAIL-R2; KILLER/DR5; DR5; KILLER; TRAILR2; TRICK2; ZTNFR9; TRAIL receptor 2; TRAIL-R2] |
| Gene, Accession # | [CD262], Gene ID: 8795, NCBI: NP_003833.4 |
| Catalog # | MBS224046 |
| Price | $470 |
| Order / More Info | Human CD262 Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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