PI3-kinase p85-alpha Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | PI3-kinase p85-alpha |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL, 0.2 mL |
| Concentration | 1mg/ml |
| Applications | Western Blot (WB), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: PI3-kinase p85-alpha antibody detects endogenous levels of total PI3-kinase p85-alpha. Description: PIK3R1 is a regulatory subunit of phosphoinositide-3-kinase. Mediates binding to a subset of tyrosine-phosphorylated proteins through its SH2 domain. Acts as an adapter, mediating the association of the p110 catalytic unit of the alpha, beta and delta enzymes to the plasma membrane, where p110 phosphorylates inositol lipids. May play an additional role in the regulation of the actin cytoskeleton. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues.Function: Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, me |
| Immunogen | Immunogen: A synthesized peptide derived from human PI3-kinase p85-alpha Subcellular Location: Cytoplasmic Tissue Specificity: Isoform 2 is expressed in skeletal muscle and brain, and at lower levels in kidney and cardiac muscle. Isoform 2 and isoform 4 are present in skeletal muscle (at protein level). Predicted Cross Reactivity: Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus Similarity: Bovine (100%), Horse (100%), Sheep (100%), Rabbit (100%), Dog (100%), Chicken (86%), Xenopus (86%) |
| Other Names | [GRB 1; GRB1; p85 alpha; p85; P85A_HUMAN; Phosphatidylinositol 3 kinase associated p 85 alpha; Phosphatidylinositol 3 kinase regulatory 1; Phosphatidylinositol 3 kinase regulatory subunit alpha; Phosphatidylinositol 3 kinase regulatory subunit polypeptide 1 (p85 alpha); Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; Phosphatidylinositol 3-kinase regulatory subunit alpha; Phosphoinositide 3 kinase regulatory subunit 1 (alpha); Phosphoinositide 3 kinase regulatory subunit 1 (p85 alpha); Phosphoinositide 3 kinase regulatory subunit 1; Phosphoinositide 3 kinase regulatory subunit polypeptide 1 (p85 alpha); PI3 kinase p85 subunit alpha; PI3-kinase regulatory subunit alpha; PI3-kinase subunit p85-alpha; PI3K; PI3K regulatory subunit alpha; Pik3r1; PtdIns 3 kinase p85 alpha; PtdIns-3-kinase regulatory subunit alpha; PtdIns-3-kinase regulatory subunit p85-alpha] |
| Gene, Accession # | [PIK3R1], Gene ID: 5295, NCBI: NP_001229395.1, UniProt: P27986 |
| Catalog # | MBS9601831 |
| Price | $240, $280 |
| Order / More Info | PI3-kinase p85-alpha Antibody from MYBIOSOURCE INC. |
| Product Specific References | Li ZH, Xiong QY, Xu L, Duan P, Yang QO, Zhou P, Tu JH; Journal: Oncotarget. miR-29a regulated ER-positive breast cancer cell growth and invasion and is involved in the insulin signaling pathway. Liu Y, Geng L, Zhang J, Wang J, Zhang Q, Duan D, Zhang Q; Journal: Mar Drugs. Oligo-Porphyran Ameliorates Neurobehavioral Deficits in Parkinsonian Mice by Regulating the PI3K/Akt/Bcl-2 Pathway. Wang W, Li L, Chen F, Yang Y; Journal: Oncol Rep. Umbilical cord-derived mesenchymal stem cells can inhibit the biological functions of melanoma A375 cells. |
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