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Antigenic Specificity | GPS2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.03 mL, 0.1 mL, 0.2 mL |
Concentration | 1 mg/ml |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: GPS2 Polyclonal Antibody detects endogenous levels of GPS2 protein. GPS2 encodes G protein pathway suppressor 2 involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. |
Immunogen | Immunogen: Synthesized peptide derived from the N-terminal region of human GPS2 at AA rangle: 30-110 |
Other Names | [Rabbit GPS2; GPS2; G protein pathway suppressor 2; GPS-2] |
Gene, Accession # | [GPS2], Gene ID: 2874, NCBI: NP_004480.1, UniProt: Q13227 |
Catalog # | MBS9705268 |
Price | $130, $220, $325 |
Order / More Info | GPS2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |