IkBa Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | IkBa |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, rat, mouse, bovine, chicken, dog |
| Isotype | n/a |
| Format | epitope affinity purified |
| Size | 0.1 mg |
| Concentration | Size: 100 ug/200 ul |
| Applications | ELISA, Western Blot, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This antibody recognizes ~42 kDa of human IkBa. This antibody also reacts with rat and mouse. The other species are not tested. There are six members in the IkB family, in which IkBa is first protein induced by NF-kB activation. NF-kB is silenced in the cytoplasm by an inhibitory protein, IkB. Synthesis of IkBa is autoregulated. IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins, IKK1/a, IKK2/b, and IKK3/g. External stimuli such as TNF or other cytokines initiates a signal transduction cascade that leads to the activation of IkB-kinase complex that specifically phosphorylates IkBa on Serine-32 and Serine-36. Phosphorylation of these sites leads to ubiquitination of IkBa and subsequent degradation by |
| Immunogen | Antigen Preparation: A synthetic peptide corresponding to the N-terminus of human IkBalpha protein. This sequence is identical within human, mouse, rat, dog and bovine. |
| Other Names | [Rabbit IkBa; I kappa B alpha; IkBa; IkappaBalpha; MAD3.], [NFKBIA; NFKBIA; IKBA; MAD-3; NFKBI; IKBA; MAD3; NFKBI] |
| Gene, Accession # | [IkBa (NFKB1A)], Gene ID: 4792, UniProt: P25963 |
| Catalog # | MBS462221 |
| Price | $245 |
| Order / More Info | IkBa Antibody from MYBIOSOURCE INC. |
| Product Specific References | Carole Kretz-Remy, et al. Inhibition of IKB-a Phosphorylation and Degradation and Subsequent NF-KB Activation by Glutathione Peroxidase Overexpression. (1996) The Journal of Cell Biology, 133 (5), 1083-1093. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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