Edit |   |
---|---|
Antigenic Specificity | Bcl-rambo |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Members of the Bcl-2 family are known to be critical regulators of this process. These proteins are characterized by the presence of several conserved motifs termed Bcl-2 homology (BH) domains. A novel, widely expressed member termed Bcl-rambo was recently identified. This protein is localized to mitochondria in mammalian cells and its overexpression induces apoptosis which could be blocked by co-expression of inhibitor of apoptosis proteins (IAPs) such as XIAP, cIAP1, and cIAP2. Bcl-rambo shows overall homology to the anti-apoptotic members con |
Immunogen | Immunogen Type: Peptide Immunogen Description: Raised against a 15 amino acid peptide from near the center of human Bcl-rambo. |
Other Names | [Bcl-2 like protein 13, Mil1] |
Gene, Accession # | Gene ID: 23786, NCBI: AAH07658 |
Catalog # | MBS9408153 |
Price | $320 |
Order / More Info | Bcl-rambo Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |