Rad50 Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | Rad50 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.05 mL, 0.1 mL, 0.2 mL |
| Concentration | n/a |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The DNA repair protein Rad50 is a member of the structural maintenance of chromosomes family (SMC) and plays an important role in cell cycle checkpoint signaling and doublestrand break repair in response to DNA damage (1-4). Rad50 forms a complex with Mre11 and Nbs1 that becomes activated in response to DNA damage (3). In normal human cells, the MRN complex acts to tether linear DNA molecules, providing a flexible link between DNA ends (1). Genomic instability and cancer have been shown to develop in cells with genetic mutations affecting the proteins in the MRN complex (2). |
| Immunogen | Immunogen: A synthetic -peptide of human Rad50 |
| Other Names | [RAD50; RAD50; NBSLD; RAD502; hRad50; DNA repair protein RAD50;], [RAD50; RAD50; NBSLD; RAD502; hRad50; hRAD50] |
| Gene, Accession # | Gene ID: 10111, NCBI: NP_005723.2, UniProt: Q92878 |
| Catalog # | MBS125532 |
| Price | $200, $275, $430 |
| Order / More Info | Rad50 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. de Jager, M. et al. (2001) Mol. Cell 8, 1129-1135. 2. Elledge, S.J. (1996) Science 274, 1664-1672. 3. Lee, J.H. and Lim, D.S. (2006) FEBS J. 273, 1630-1636. 4. Teng, S.C. et al. (2006) J Mol Histol 37, 29-39. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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http://www.MyBioSource.com
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