Edit |   |
---|---|
Antigenic Specificity | Bcl-xL |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mg |
Concentration | 500 ug/ml |
Applications | Immunoprecipitation (IP), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Bcl-xL is a 30 kDa anti-apoptotic protein belonging to the Bcl-2 family. Bcl-xL prevents apoptosis through two different mechanisms: by heterodimerization with an apoptotic protein to inhibit its apoptotic effect, and by its direct pore-forming effect on the outer-membrane of mitochondria to help maintain a normal membrane state under stress conditions. Bcl-xL can be cleaved by caspases upon apoptotic activation, which converts Bcl-xL from an antiapoptotic protein to a proapoptotic cleavage product. The cleavage product of Bcl-xL forms cytochrome c-releasing pores in the mitochondrial membrane to facilitate the apoptosis signaling pathway. |
Immunogen | Immunogen: Bcl-xL antibody was raised in Rabbit using synthetic peptide surrounding amino acid 56 of human Bcl-xL as the immunogen. |
Other Names | [Rabbit Bcl-xL; Bcl-xL; Bcl-xL; Bcl-xS; Bcl-xL; BCL2L1; BCL2-like 1 protein] |
Gene, Accession # | [Bcl-xL], Gene ID: 598 |
Catalog # | MBS5311257 |
Price | $500 |
Order / More Info | Bcl-xL Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |