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Antigenic Specificity | Cyclin E1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat, bovine, dog, porcine |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.05 mL |
Concentration | 1 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Polyclonal Antibody to detect Cyclin E1 in human, mouse, rat, bovine, dog and pig samples. Background: Cyclin E1 is a regulatory subunit of the CDK2 kinase. It is central for the regulation of the G1/S transition and its abundance is tightly regulated throughout the cell cycle via ubiquitination. Cyclin E has been the subject of intense study in relation to tumorigenesis and cancer management and prognosis. Multiple isoforms of Cyclin E are only expressed in tumors but not in normal tissue, suggesting a post transcriptional regulation of Cyclin E. In vitro analyses indicated that these truncated variant isoforms of Cyclin E are able to phosphorylate histone H1. Alterations in the Cyclin E protein have been implicated as indicators of worse |
Immunogen | Immunogen: This Cyclin E1 antibody is generated from KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Cyclin E1. The exact sequence is proprietary. Positive Control: WB: HEK293T, mouse brain, PC12, SW626, HeLa, K562, whole cell lysates, IHC: human lung cancer, IC/IF: PC12 cells |
Other Names | [CCNE1; Cyclin Es; Cyclin Et; G1/S-specific cyclin-E1], [CCNE1; CCNE1; CCNE; pCCNE1; CCNE] |
Gene, Accession # | Gene ID: 898, NCBI: NP_001229.1, UniProt: P24864 |
Catalog # | MBS840321 |
Price | $240 |
Order / More Info | Cyclin E1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |