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Antigenic Specificity | MYOC |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: MYOC antibody detects endogenous levels of total MYOC. Description: Myocilin (MYOC), also known as TIGR or GLC1A, is a secreted glycoprotein of the olfactomedin family, originally identified in trabecular meshwork cells after prolonged treatment with glucocorticoids, and, independently, in the retina (PMID: 9176893; 9169133). It may participate in the obstruction of fluid outflow in the trabecular meshwork. Defects in MYOC are the cause of primary open angle glaucoma (POAG) (PMID: 21709622). MYOC has a molecular weight of 55-57 kDa, besides, a 66-kDa form, which could be a result of post-translational modifications, has also been reported in some researches (PMID: 9497363; 12150989).Function: Secreted glycoprotein regulatin |
Immunogen | Immunogen: A synthesized peptide derived from human MYOC Subcellular Location: Rough Endoplasmic Reticulum. Secreted. Cell Projection > Cilium. Located preferentially in the ciliary rootlet and basal body of the connecting cilium of photoreceptor cells, and in the rough endoplasmic reticulum. Also secreted. Tissue Specificity: Detected in aqueous humor (PubMed:12697062). Detected in the eye (at protein level) (PubMed:11431441). Widely expressed. Highly expressed in various types of muscle, cilia |
Other Names | [GLC1A; GPOA; JOAG; JOAG1; Mutated trabecular meshwork-induced glucocorticoid response protein; MYOC; MYOC_HUMAN; Myocilin; Myocilin, trabecular meshwork inducible glucocorticoid; TIGR; Trabecular meshwork induced glucocorticoid response protein; Trabecular meshwork-induced glucocorticoid response protein] |
Gene, Accession # | [MYOC], Gene ID: 4653, NCBI: NP_000252.1, UniProt: Q99972 |
Catalog # | MBS9607139 |
Price | $240, $280 |
Order / More Info | MYOC Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |