Phospho-Thr1007 Potassium Chloride Cotransporter (KCC2) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Phospho-Thr1007 Potassium Chloride Cotransporter (KCC2) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | mouse, rat. predicted: bovine, human, nonhuman primate, porcine, sheep |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Specific for endogenous levels of the ~135 kDa KCC2 protein phosphorylated at Thr1007. Immunolabeling is completely eliminated by treatment with Lambda-Ptase. KCC2 is widely thought to be expressed exclusively in neurons where it is responsible for maintaining low intracellular chloride concentration to drive hyperpolarizing post-synaptic responses to the inhibitory neurotransmitters GABA and glycine (Lee et al., 2007). KCC2 is expressed in most adult neurons, and expression levels correlate well with the maturation state of neurons. N-ethylmaleimide (NEM) has been show to increase phosphorylation of the Ser940 residue, while decreasing phosphorylation of T1007 residue. Dephosphorylation of residues T906 and T1007 correlates wi |
| Immunogen | Immunogen Species: Rat. Immunogen Information: Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser940 conjugated to KLH. |
| Other Names | [solute carrier family 12 member 5; Solute carrier family 12 member 5; solute carrier family 12 member 5; solute carrier family 12 member 5; Electroneutral potassium-chloride cotransporter 2; Furosemide-sensitive K-Cl cotransporter; K-Cl cotransporter 2; rKCC2; Neuronal K-Cl cotransporter], [Slc12a5; Slc12a5; Kcc2; Kcc2; rKCC2] |
| Gene, Accession # | [KCC2], Gene ID: 171373, NCBI: NP_599190.1, UniProt: Q63633 |
| Catalog # | MBS500088 |
| Price | $360 |
| Order / More Info | Phospho-Thr1007 Potassium Chloride Cotransporter (KCC2) Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Conway, L.C., Cardarelli, R.A., Moore, Y.E., Jones, K., McWilliams, L.J., Baker, D.J., Burnham, M.P., Burli, R.W., Wang, Q., Brandon, N.J. and Moss, S.J., 2017. N-ethylmaleimide increases KCC2 activity by modulating transporter phosphorylation. Journal of Biological Chemistry, pp.jbc-M117. 2. Lee HH, Walker JA, Williams JR, Goodier RJ, Payne JA, Moss SJ (2007) Direct protein kinase C-dependent phosphorylation regulates the cell surface stability and activity of the potassium chloride cotransporter KCC2. J Biol Chem. 2007 Oct 12; 282(41):29777-84. |
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