Cyclin O Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityCyclin O
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman, mouse, rat
Isotypen/a
Formatpeptide affinity purified
Size0.1 mg
Concentration1 mg/mL
ApplicationsELISA (EIA), Western Blot (WB)
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DescriptionSpecificity: At least two isoforms of Cyclin O are known to exist; this antibody will recognize both isoforms. Cyclin O Antibody: Cyclin O, also known as CCNO, has recently been identified as a Cdk1- and Cdk2-activating cyclin specific to apoptosis in lymphoid cells. Cyclin O binds to and activates Cdk2 in response to instrinsic apoptotic stimuli such as glucocorticoids or DNA-damaging agents. Supression of Cyclin O expression by shRNA leads to the inhibition of glucocorticoid and DNA-damage-induced apoptosis due to a failure of apical caspase activation while leaving the CD95 death receptor-mediated apoptosis intact. Note: this gene, which had a previous symbol of UNG2, was erroneously identified as a uracil DNA glycosylase. A later public
ImmunogenImmunogen: Cyclin O antibody was raised against a 13 amino acid synthetic peptide from near the center of human Cyclin O. Buffer: Cyclin O Antibody is supplied in PBS containing 0.02% sodium azide.
Other Names[Cyclin O; CCNU; UDG2; Cyclin-O; Cyclin O], [CCNO; CCNO; CCNU; UDG2; CILD29]
Gene, Accession #[CCNO], Gene ID: 10309, NCBI: NP_066970, UniProt: P22674
Catalog #MBS150476
Price$375
Order / More InfoCyclin O Antibody from MYBIOSOURCE INC.
Product Specific Referencesn/a
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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