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Antigenic Specificity | Cyclin O |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mg |
Concentration | 1 mg/mL |
Applications | ELISA (EIA), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: At least two isoforms of Cyclin O are known to exist; this antibody will recognize both isoforms. Cyclin O Antibody: Cyclin O, also known as CCNO, has recently been identified as a Cdk1- and Cdk2-activating cyclin specific to apoptosis in lymphoid cells. Cyclin O binds to and activates Cdk2 in response to instrinsic apoptotic stimuli such as glucocorticoids or DNA-damaging agents. Supression of Cyclin O expression by shRNA leads to the inhibition of glucocorticoid and DNA-damage-induced apoptosis due to a failure of apical caspase activation while leaving the CD95 death receptor-mediated apoptosis intact. Note: this gene, which had a previous symbol of UNG2, was erroneously identified as a uracil DNA glycosylase. A later public |
Immunogen | Immunogen: Cyclin O antibody was raised against a 13 amino acid synthetic peptide from near the center of human Cyclin O. Buffer: Cyclin O Antibody is supplied in PBS containing 0.02% sodium azide. |
Other Names | [Cyclin O; CCNU; UDG2; Cyclin-O; Cyclin O], [CCNO; CCNO; CCNU; UDG2; CILD29] |
Gene, Accession # | [CCNO], Gene ID: 10309, NCBI: NP_066970, UniProt: P22674 |
Catalog # | MBS150476 |
Price | $375 |
Order / More Info | Cyclin O Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |