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Antigenic Specificity | EZH1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemisty (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: EZH1 antibody detects endogenous levels of total EZH1. Function: Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di-and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper |
Immunogen | Immunogen: A synthesized peptide derived from human EZH1 Subcellular Location: Nucleus. Colocalizes with trimethylated 'Lys-27' of histone H3. Predicted Cross Reactivity: Pig, Bovine, Horse, Sheep, Dog Similarity: Pig (92%), Bovine (100%), Horse (100%), Sheep (100%), Dog (100%) |
Other Names | [Enhancer of zeste homolog 1 (Drosophila); Enhancer of zeste homolog 1; ENX-2; ENX2; Ezh1; EZH1_HUMAN; Histone-lysine N-methyltransferase EZH1] |
Gene, Accession # | [EZH1], Gene ID: 2145, NCBI: NP_001308008.1, UniProt: Q92800 |
Catalog # | MBS9601422 |
Price | $240, $280 |
Order / More Info | EZH1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |