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Antigenic Specificity | CBFA2T3 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway (PubMed:25974097). Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 305-390 of human CBFA2T3 (NP 005178.4). |
Other Names | [ETO2; MTG16; MTGR2; ZMYND4; RUNX1T3] |
Gene, Accession # | [CBFA2T3], Gene ID: 863, NCBI: NP_005178.4, UniProt: O75081 |
Catalog # | MBS8549570 |
Price | $280 |
Order / More Info | CBFA2T3 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |