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Antigenic Specificity | USP10 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulato |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 499-798 of human USP10 (NP 005144.2). |
Other Names | [UBPO] |
Gene, Accession # | [USP10], Gene ID: 9100, NCBI: NP_001259004.1, UniProt: Q14694 |
Catalog # | MBS8546864 |
Price | $280 |
Order / More Info | USP10 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |