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Antigenic Specificity | Transferrin Receptor (CD71) |
Clone | monoclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.03 mg, 0.1 mg, 0.1 mg |
Concentration | n/a |
Applications | Flow Cytometry (FC/FACS), Immunoprecipitation (IP), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. |
Immunogen | Immunogen: A synthesized peptide derived from human TFR. Subcellular Localization: Cell membrane; Single-pass type II membrane protein. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. |
Other Names | [Transferrin receptor protein 1; TR; TfR; TfR1; Trfr; T9; p90; CD71; Transferrin receptor protein 1; serum form; sTfR; TFRC], [TFRC; TFRC; T9; TR; TFR; p90; CD71; TFR1; TRFR; IMD46; TR; TfR; TfR1; Trfr; sTfR] |
Gene, Accession # | [TFRC], Gene ID: 7037, NCBI: NP_001121620.1, UniProt: P02786 |
Catalog # | MBS179381 |
Price | $160, $340, $340 |
Order / More Info | Transferrin Receptor (CD71) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |