Description | Specificity: Human CD23. CD23 is a 45 kDa type II integral membrane glycoprotein that is the low affinity receptor for IgE. It also binds to CD21, and the alpha chains of CD11b and CD11c. It is expressed by B cells and monocytes and, weakly, on T cells, follicular dendritic cells, eosinophils, NK cells, Langerhans cells and platelets. It is upregulated in response to B cell activation, CD40 ligation, or in response to IL-4 or IL-13. CD23 is responsible for regulation of IgE synthesis and may play a role in antigen presentation by B cells andfollicular dendritic cells by interacting with CD40.1-7. |
Product Specific References | 1. McMichael, A.K., P.C.L. Beverly, S. Cobbold, M.J. Crumpton, W. Gilks, F.M. Gotch, N. Hogg, M. Horton, N. Ling, I.C.M. MacLennan, D.Y. Mason, C. Milstein, D. Spiegelhalter, and H. Waldmann, eds. 1987. Leukocyte Typing III: White Cell Differentiation Antigens, Oxford University Press, Oxford.2. Knapp, W., B. Dorken, W.R. GIlks, E.P. Rieber, R.E. Schmidt, H. Stein, A.E.G.K. Von dem Borne, eds. 1989. Leukocyte Typing IV: White Cell Differentiation Antigens, Oxford University Press, Oxford.3. Barclay, A.N., M.H. Brown, S.K.A. Law, A.J. McKnight, M.G. Tomlinson, and P.A. van der Merwe, eds. 1997. The Leukocyte Antigens Facts Book, 2nd Edition, CD23 Section, Academic Press, New York, p. 189.4. Gordon, J. 1991. Clin. Exp. Immunol. 86:356.5. Bonnefoy, J.-Y, S. Lecoanet-Henchoz, J.P. Aubry, J.F. Gauchat, and P. Graber. 1995. Curr. Opin. Immunol. 7:355.6. Bonnefoy, J.-Y., C. Plater-Zyberk, S. Lecoanet-Henchoz, J.-F. Gauchat, J.-P. Aubry, and P. Graber. 1996. Immunol. Today 17:418.7. Lamers, M.C., and P. Yu, 1995. Immunol. Rev. 148:71. |