IL10 Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | IL10 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL, 0.2 mL |
| Concentration | 1mg/ml |
| Applications | Western Blot (WB), Immunohistochemisty (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: IL10 antibody detects endogenous levels of total IL10. Description: IL-10 is an anti-inflammatory cytokine that is produced by T cells, NK cells and macrophages (1, 2). IL-10 initiates signal transduction by binding to a cell surface receptor complex consisting of IL-10 RI and IL-10 RII (1). Binding of IL-10 leads to the activation of Jak1 and Tyk2, which phosphorylates Stat-3 (1, 3). The anti-inflammatory activity of IL-10 is due to its ability to block signaling through other cytokine receptors, notably IFNgamma receptor, by upregulating expression of SOCS-1 (1, 3). In addition, IL-10 promotes T cell tolerance by inhibiting tyrosine phosphorylation of CD28 (4, 5). IL-10 is an important negative regulator of the immune respons |
| Immunogen | Immunogen: A synthesized peptide derived from human IL10 Subcellular Location: Secreted. Tissue Specificity: Produced by a variety of cell lines, including T-cells, macrophages, mast cells and other cell types. Predicted Cross Reactivity: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Xenopus Similarity: Pig (83%), Bovine (100%), Horse (100%), Sheep (100%), Rabbit (89%), Dog (100%), Xenopus (89%) |
| Other Names | [CSIF; Cytokine synthesis inhibitory factor; GVHDS; IL 10; IL-10; IL10; IL10_HUMAN; IL10A; Interleukin 10; Interleukin-10; MGC126450; MGC126451; T-cell growth inhibitory factor; TGIF] |
| Gene, Accession # | [IL10], Gene ID: 3586, NCBI: NP_000563.1, UniProt: P22301 |
| Catalog # | MBS9607547 |
| Price | $240, $280 |
| Order / More Info | IL10 Antibody from MYBIOSOURCE INC. |
| Product Specific References | Wang S, Wei J, Fan Y, Ding H, Tian H, Zhou X, Cheng L; Journal: Inflammation. Progranulin Is Positively Associated with Intervertebral Disc Degeneration by Interaction with IL-10 and IL-17 Through TNF Pathways. Hu J, Cheng P, Huang GY, Cai GW, Lian FZ, Wang XY, Gao S; Journal: Phytomedicine. Effects of Xin-Ji-Er-Kang on heart failure induced by myocardial infarction: Role of inflammation, oxidative stress and endothelial dysfunction. Wen L, You W, Wang H, Meng Y, Feng J, Yang X; Journal: J Neurotrauma. Polarization of Microglia to the M2 Phenotype in a Peroxisome Proliferator-Activated Receptor Gamma-Dependent Manner Attenuates Axonal Injury Induced by Traumatic Brain Injury in Mice. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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