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Antigenic Specificity | Phospho- beta-Catenin (S37) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, rat, mouse |
Isotype | n/a |
Format | epitope affinity purified |
Size | 0.1 mg |
Concentration | Size: 100 ug/200 ul |
Applications | ELISA, Western Blot, Immunohistochemistry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This antibody recognizes ~88 kDa of human beta-Catenin protein. It also reacts with mouse and rat. The other species are not tested. Beta-catenin is a cytosolic, 88 kDa, 781 amino acid protein belongs to the beta-catenin family. The N-terminus domain, containing the binding site and the phosphorylation sites. Beta-Catenin serves as a link between cytoskeleton actin and transmembrane cadherin (s). It is believed to contribute to tight cell-to-cell adhesion. It can enter the nucleus and interact with the TCF/LEF family of transcription factors, initiating gene expression. Normally, beta-catenin transcriptional activity is suppressed by a Ser/Thr kinase termed GSK3beta and/or Casein Kinase I (CK1). Kinases are constitutively active and phospho |
Immunogen | Antigen Preparation: A synthetic peptide corresponding to the epitope SGIHS with a single phosphorylation site Ser37 of human beta-catenin. |
Other Names | [Rabbit beta-Catenin (pS37)], [ctnnb1; ctnnb1; ctnnb; id:ibd2058; wu:fb73e10; wu:fi81c06; wu:fk25h01] |
Gene, Accession # | [b-Catenin (pS37)], Gene ID: 30265, UniProt: Q7ZU14 |
Catalog # | MBS462018 |
Price | $285 |
Order / More Info | Phospho- beta-Catenin (S37) Antibody from MYBIOSOURCE INC. |
Product Specific References | Park, C.S. et al. (2004) J. Biol. Chem. 279:19592. |