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Antigenic Specificity | NR1D1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunoprecipitation (IP) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Reverse orientation c-erbA gene alpha (Rev-erbalpha, EAR-1, or NR1D1) is a widely expressed member of the orphan nuclear receptor family of proteins (1). Rev-erbalpha is highly expressed in adipose tissue, skeletal muscle, brain and liver, and regulates cellular proliferation and differentiation. Expression increases during differentiation in adipocytes and ectopic expression of Rev-erbalpha potentiates the adipocyte differentiation of 3T3-L1 cells (2). In addition, expression oscillates with circadian rhythm in liver cells and Rev-erbalpha regulates expression of BMAL1, ApoA-I and ApoC-III, all key regulators of circadian rhythm (3,4,5,6,7). Phosphorylation of Rev-erbalpha Ser55 and Ser59 by GSK3beta appears to stabilize Rev-erbalpha prote |
Immunogen | Immunogen: Recombinant Protein |
Other Names | [Rev-erbalpha: Rev-erba; NR1D1; EAR1; THRA1; THRAL; ear-1; hRev], [NR1D1; NR1D1; EAR1; hRev; THRA1; THRAL; ear-1; EAR1; HREV; THRAL; EAR-1] |
Gene, Accession # | [NR1D1], Gene ID: 9572, NCBI: P20393.1, UniProt: P20393 |
Catalog # | MBS127846 |
Price | $235, $350 |
Order / More Info | NR1D1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |