Edit |   |
---|---|
Antigenic Specificity | INS |
Clone | monoclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | IgG |
Format | affinity purified |
Size | 0.05 mL, 0.1 mL, 0.2 mL |
Concentration | n/a |
Applications | Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. |
Immunogen | Immunogen: Recombinant protein of human INS |
Other Names | [IDDM; IDDM1; IDDM2; ILPR; IRDN; MODY10] |
Gene, Accession # | [INS], Gene ID: 3630, NCBI: P01308.1, UniProt: P01308 |
Catalog # | MBS9131233 |
Price | $235, $350, $525 |
Order / More Info | INS Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |