Edit |   |
---|---|
Antigenic Specificity | Smac |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Smac Antibody: The inhibitor of apoptosis proteins (IAPs) regulate programmed cell death by inhibiting members of the caspase family of enzymes. A novel mammalian protein that binds to IAPs and neutralizes the inhibitory effect of IAPs on caspases was recently identified and designated Smac/DIABLO. Smac/DIABLO is a mitochondrial protein that is released along with cytochrome c during apoptosis and activates cytochrome c/Apaf-1/capase-9 pathway. Analysis of the structural basis of Smac/DIABLO reveals that the N-terminal amino acids are required for binding of Smac/DIABLO to IAPs and activation of caspases. Smac/DIABLO is expressed in a variety of human and mouse tissues. |
Immunogen | Immunogen: Smac antibody was raised against a 15 amino acid peptide near the carboxy terminus of human Smac. Buffer: Smac Antibody is supplied in PBS containing 0.02% sodium azide. |
Other Names | [Smac; Smac; AU040403; 0610041G12Rik; 1700006L01Rik; Smac; Diablo homolog; mitochondrial; Direct IAP-binding protein with low pI; diablo homolog (Drosophila)], [Diablo; Diablo; Smac; AU040403; 0610041G12Rik; 1700006L01Rik; Smac; Smac] |
Gene, Accession # | [Diablo], Gene ID: 66593, NCBI: AF203914, UniProt: Q9JIQ3 |
Catalog # | MBS150750 |
Price | $375 |
Order / More Info | Smac Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |