Mouse H-2Db-APC Antibody from MYBIOSOURCE INC.
Search, find, compare suppliers for anti-Mouse H-2Db-APC antibody, protein, ELISA kits.
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| Antigenic Specificity | Mouse H-2Db-APC |
| Clone | polyclonal |
| Host Species | Mouse |
| Reactive Species | mouse |
| Isotype | n/a |
| Format | unconjugated |
| Size | 0.1 mg |
| Concentration | 0.1 mg/mL |
| Applications | Flow Cytometry (FC/FACS), Immunohistochemistry (IHC) Formalin, Immunoprecipitation (IP), Blocking (BL), Complement Mediated Cell Depletion |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Mouse H-2Db. The classical MHC Class I molecules are histocompatibility antigens encoded by the H-2 gene complex and consist of heterodimers of highly polymorphic alpha chains noncovalently associated with the invariant beta2-microglobulin. These antigens are expressed on most nucleated cells but expression varies on different cell types. MHC Class I molecules present endogenously synthesized peptides to CD8+ T lymphocytes which are usually cytotoxic T cells. MHC Class I antigens expressed on thymic epithelial cells regulate the positive and negative selection of CD8+ T cells during T cell ontogeny. The monoclonal antibody 28-14-8 binds to the alpha3 domain of H-2Db in the presence or absence of beta2 microglobulin. It cross |
| Immunogen | Immunogen: C3H.SW mouse splenocytes |
| Other Names | n/a |
| Gene, Accession # | [H-2DbC] |
| Catalog # | MBS679286 |
| Price | $260 |
| Order / More Info | Mouse H-2Db-APC Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Ozato K, Hansen TH, Sachs DH. Monoclonal antibodies to mouse MHC antigens. II. Antibodies to the H-2Ld antigen, the products of a third polymorphic locus of the mouse major histocompatibility complex. J Immunol. 1980;125:2473-7. (Immunogen, CMDC). 2. Allen H, Fraser J, Flyer D, Calvin S, Flavell R. beta2-microglobulin is not required for cell surface expression of the murine class I histocompatibility antigen H-2Db or of a truncated H-2Db. Proc Natl Acad Sci USA. 1986;83:7447-51. (IP). 3. Lie W, Myers NB, Connolly JM, Gorka J, Lee DR, Hansen TH. The specific binding of peptide ligand to Ld class I major histocompatibility complex molecules determines their antigenic structure. J Exp Med. 1991;173:449-59. (IP). 4. Levitsky HI, Lazenby A, Hayashi RJ, Pardoll DM. In vivo priming of two distinct antitumor effector populations: the role of MHC class I expression. J Exp Med. 1994;179:1215-24. (FC, IHC-FS). 5. Ozato K, Sachs DH. Monoclonal antibodies to mouse MHC antigens. III. Hybridoma antibodies reacting to antigens of the H-2b haplotype reveal genetic control of isotype expression. J Immunol. 1981;126:317-21. (Immunogen, CMDC). 6. Woodward JG, Orn A, Harmon RC, Goodenow RS, Hood L, Frelinger JA. Specific recognition of the product of a transferred major histocompatibility complex gene by cytotoxic T lymphocytes. Proc Natl Acad Sci USA. 1982;79:3613-7. (CMDC, Block). 7. Wang R, Rogers AM, Ratliff TL, Russell JH. CD95-dependent bystander lysis caused by CD4 T helper 1 effectors. J Immunol. 1996;157:2961-8. (FC). 8. Lee S, Bar-Haim E, Machlenkin A, Goldberger O, Volovitz I, Vadai E, et al. In vivo rejection of tumor cells dependent on CD8 cells that kill independently of perforin and FasL. Cancer Gene Ther. 2004;11:237-48. (FC) |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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